Top 50 MedTech Venture Capital (VC) Firms
Finding the right partner can make or break a MedTech startup. This MedTech Venture Capital list presents the top 50 investors actively deploying capital across the United States in 2025. These firms back companies working in medical technology, medical devices, diagnostics, healthtech and related areas at stages ranging from seed to late-round financing. Use this list as a practical starting point for your 2025 fundraising efforts.
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The top 50 MedTech Venture Capital Firms
1. OrbiMed
OrbiMed, based in New York, focuses on global investments across the healthcare sector, including medical devices, diagnostics, digital health, biopharma, and services. It supports companies at all stages from early-stage private ventures to large public firms with tailored financing and scientific expertise. OrbiMed is distinguished by its long-standing presence and large scale in health sciences investing.
Location: New York NY
2. Venture Investors
Venture Investors, based in Madison, Wisconsin, specializes in early-stage investments in healthcare and technology companies, with a particular focus on medical devices and diagnostics. Leveraging its proximity to top-tier research institutions like the University of Wisconsin–Madison and the University of Michigan, the firm has invested in over 40 university ecosystem spinouts. Venture Investors is known for its deep integration with academic research and its commitment to transforming groundbreaking innovations into commercial successes.
Location: Madison WI
3. BioGenerator
BioGenerator Ventures, based in St. Louis, Missouri, is the investment arm of BioSTL, focusing on early-stage companies addressing challenges in human health and agriculture. The firm has invested in over 130 companies, leveraging its strong connections with local research institutions like Washington University in St. Louis. BioGenerator Ventures is recognized for its deep integration with the St. Louis bioscience ecosystem.
Location: St. Louis MO
4. SOSV
SOSV, based in Princeton, New Jersey, is a global, multi-stage venture capital firm that invests in deep tech startups, with a strong emphasis on human and planetary health. Through its programs, HAX and IndieBio, SOSV provides early-stage funding and hands-on support to companies in sectors such as medical devices, diagnostics, and therapeutics. The firm is recognized for its commitment to transforming scientific innovations into scalable, impactful businesses.
Location: Princeton NJ
5. Accelmed
Accelmed, based in Miami, Florida, is a private equity firm specializing in U.S. commercial-stage healthtech investments. The firm focuses on lower middle-market companies in sectors such as medical devices, diagnostics, digital health, and technology-enabled healthcare services. Accelmed is recognized for its operational expertise and hands-on approach, partnering closely with portfolio companies to drive growth and innovation. Since its inception in 2009, Accelmed has deployed over $400 million into healthtech ventures.
Location: Miami FL
6. Hatteras Venture Partners
Hatteras Venture Partners, based in Durham, North Carolina, is an early-stage venture capital firm specializing in transformative investments within the life sciences sector. The firm focuses on biopharmaceuticals, medical devices, diagnostics, and healthcare IT, aiming to address significant unmet medical needs. With over $900 million under management, Hatteras has a strong track record of supporting innovative companies, including notable exits like HistoSonics and Kymera Therapeutics.
Location: Durham NC
7. SV Health Investors
SV Health Investors, based in Boston, Massachusetts, is a global healthcare investment firm managing over $4 billion across specialized funds in biotechnology, medtech, and healthcare services. Its Medtech Convergence Fund focuses on early-stage companies developing innovative medical technologies that integrate with software and digital services to enhance patient outcomes and reduce healthcare costs. The firm is recognized for its extensive experience and strategic partnerships in advancing healthcare innovation.
Location: Boston MA
8. Deerfield Management Company
Deerfield Management, based in New York City, is a healthcare investment firm managing over $15 billion in assets. The firm supports a diverse portfolio of private and public investments spanning therapeutics, medical devices, healthcare services, diagnostics, and digital health. Deerfield is recognized for its flexible funding models and its commitment to advancing healthcare through investment, intelligence, and philanthropy.
Location: New York NY
9. Vivo Capital
Vivo Capital, based in Palo Alto, California, is a global healthcare investment firm specializing in biotechnology and medical devices. The firm employs a multi-strategy investment approach encompassing venture capital, private equity, and public equity, with a focus on preclinical and clinical-stage life sciences companies developing novel therapies for unmet medical needs. Vivo Capital is recognized for its extensive experience and strategic partnerships in advancing healthcare innovation.
Location: Palo Alto CA
10. 5AM Ventures
5AM Ventures, based in San Francisco, California, is a life science venture capital firm specializing in early-stage investments in biopharmaceuticals, drug delivery technologies, and life science instruments. Founded in 2002, the firm manages over $1.2 billion across multiple funds and employs a hands-on approach to company building. 5AM Ventures is recognized for its internal initiative, the 4:59 Initiative, which partners with academics and entrepreneurs to establish proof-of-concept data, enabling Series A financing.
Location: San Francisco CA
11. Third Rock Ventures
Third Rock Ventures, based in Boston, Massachusetts, is a venture capital firm focused on creating and growing innovative life sciences companies. The firm supports ventures developing medical devices and technologies alongside therapeutics to address unmet medical needs. Third Rock Ventures is recognized for its hands-on approach and collaboration with scientific and clinical experts.
Location: Boston MA
12. Pappas Capital
Pappas Capital, based in Durham, North Carolina, is a venture capital firm investing in innovative life sciences companies. The firm focuses on early-stage medical technology ventures, helping them advance from concept to commercial-ready products. Pappas Capital is recognized for its expertise in supporting Medtech innovation through hands-on guidance and strategic partnerships.
Location: Durham NC
13. Arboretum Ventures
Arboretum Ventures, based in Ann Arbor, Michigan, is a healthcare-focused venture capital firm that invests in medical devices, life science tools, diagnostics, and tech-enabled care delivery. The firm emphasizes capital-efficient opportunities in under-ventured geographies, particularly the Midwest, and supports companies from early to growth stages. Arboretum Ventures is recognized for its hands-on approach and commitment to improving patient outcomes while reducing healthcare costs.
Location: Ann Arbor MI
14. Venrock
Venrock, based in Palo Alto, California, is a venture capital firm investing across healthcare and technology sectors. The firm has a dedicated healthcare division that supports companies in medical devices, diagnostics, and therapeutics. Venrock is recognized for its long-term investment approach and expertise in scaling innovative healthcare solutions.
Location: Palo Alto CA
15. Khosla Ventures
Khosla Ventures, based in Menlo Park, California, is a venture capital firm investing in transformative technologies across various sectors, including healthcare. The firm supports early-stage companies developing innovative medical devices, diagnostics, and digital health solutions, aiming to revolutionize patient care. Khosla Ventures is recognized for its bold approach and commitment to addressing significant societal challenges through technological advancements.
Location: Menlo Park CA
16. Google Ventures
GV (formerly Google Ventures), based in San Francisco, California, is the venture capital arm of Alphabet Inc., investing across various sectors, including healthcare. The firm has a dedicated healthcare division that supports companies in medical devices, diagnostics, therapeutics, and health tech, aiming to improve patient outcomes. GV is recognized for its data-driven approach and collaboration with founders to scale transformative healthcare innovations.
Location: San Francisco CA
17. RA Capital
RA Capital Management, based in Boston, Massachusetts, is a multi-stage investment firm specializing in evidence-based investing across the healthcare and life sciences sectors. The firm supports companies developing medical devices, diagnostics, therapeutics, and research tools, guiding them from inception through commercialization.
Location: Boston MA
18. CincyTech
CincyTech, based in Cincinnati, Ohio, is a seed-stage venture capital firm investing in transformative life sciences and digital health companies. The firm collaborates closely with regional research institutions, including Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, to commercialize innovations in medical devices, diagnostics, and therapeutics.
Location: Cincinnati OH
19. Civilization Ventures
Civilization Ventures, based in San Francisco, California, is a venture capital firm investing in early-stage life sciences and medical technology companies. The firm supports innovative Medtech solutions, including diagnostics, medical devices, and health technologies that improve patient care. Civilization Ventures is recognized for its hands-on approach and guidance to help entrepreneurs bring Medtech innovations to market.
Location: San Francisco CA
20. OCA Ventures
OCA Ventures, based in Chicago, Illinois, is an early-stage venture capital firm investing in companies with significant growth potential, primarily in technology and scalable services. The firm has a notable focus on healthcare technology, supporting innovations in medical devices, diagnostics, and digital health solutions. OCA Ventures is recognized for its hands-on approach and strategic guidance, assisting portfolio companies in navigating the complexities of the healthcare sector.
Location: Chicago IL
21. Questa Capital
Questa Capital, based in Washington, D.C., is a venture growth equity firm dedicated to transforming healthcare through investments in medical devices, healthcare technology, and services. The firm focuses on expansion-stage companies developing innovative solutions that enhance patient experiences, reduce costs, and improve population health. Questa Capital is recognized for its disciplined, research-driven approach and hands-on partnership with portfolio companies to accelerate growth and market leadership.
Location: Washington DC
22. RiverVest Venture Partners
RiverVest Venture Partners, based in St. Louis, Missouri, is a venture capital firm specializing in early-stage investments in medical devices and biopharmaceuticals. The firm focuses on developing products with a clear path to clinical approval, aiming to address significant unmet medical needs. RiverVest is recognized for founding and guiding companies from inception, leveraging its strong network and expertise in the healthcare sector.
Location: St. Louis MO
23. Longitude Capital
Longitude Capital, based in Menlo Park, California, is a healthcare-focused venture capital firm investing in medical technology, biotechnology, and health solutions companies. The firm specializes in venture growth investments, targeting companies that aim to improve clinical outcomes, enhance patient quality of life, and reduce healthcare costs. Longitude Capital is recognized for its flexible investment approach, utilizing various structures such as traditional venture capital, asset spin-outs, recapitalizations, and public investments.
Location: Menlo Park CA
24. New Enterprise Associates (NEA)
New Enterprise Associates (NEA), based in Menlo Park, California, is one of the world's largest venture capital firms, managing over $25 billion in assets. The firm invests across all stages, from seed to IPO, with a strong focus on healthcare and technology sectors. NEA's healthcare portfolio includes companies in medical devices, diagnostics, therapeutics, and digital health, reflecting its commitment to advancing innovations that improve patient outcomes.
Location: Menlo Park CA
25. Alumni Ventures
Alumni Ventures, based in Manchester, New Hampshire, is a venture capital firm that democratizes access to private market investments for accredited individual investors. Through its Healthtech Fund, the firm supports early- to growth-stage companies innovating in medical devices, diagnostics, digital health, and AI-driven care solutions. Alumni Ventures is recognized for its diversified approach, co-investing with leading firms and offering curated access to a broad portfolio of healthcare innovations.
Location: Manchester NH
26. KittyHawk
KittyHawk Ventures, based in Los Angeles, California, is a venture capital firm investing in frontier technologies across various sectors, including healthcare. The firm focuses on seed-stage investments in areas such as longevity, life sciences, and medical devices. KittyHawk Ventures is recognized for its commitment to supporting mission-driven entrepreneurs developing transformative innovations in healthcare.
Location: Los Angeles CA
27. Portfolia
Portfolia, based in San Mateo, California, is a venture capital firm specializing in thematic investments, with a strong focus on women's health and MedTech. Since launching its first FemTech Fund in 2018, Portfolia has led the way in addressing unmet needs in women's health and active aging through venture capital. With over 45 investments in healthcare companies like Maven Clinic, Everly Health, and Hera Biotech, Portfolia is shaping the future of MedTech and advancing solutions for global health challenges.
Location: San Mateo CA
28. S32
S32, based in Los Altos, California, is a venture capital firm founded by Bill Maris, the original CEO of Google Ventures. The firm specializes in investing at the frontiers of technology and healthcare, focusing on areas such as artificial intelligence, quantum computing, and biotechnology. S32 is recognized for its founder-centric approach, providing strategic guidance and resources to help entrepreneurs bring transformative innovations to market.
Location: Los Altos CA
29. Plug and Play Ventures
Plug and Play Ventures, based in Sunnyvale, California, is a global venture capital firm specializing in early-stage investments across various sectors, including MedTech. The firm operates accelerator programs that connect startups with corporate partners to foster innovation in medical technologies, such as diagnostics, medical devices, and digital health solutions. Plug and Play Ventures is recognized for its extensive network and resources, providing startups with mentorship, funding, and strategic partnerships to accelerate their growth in the MedTech industry.
Location: Sunnyvale CA
30. Canaan Partners
Canaan Partners, based in Stamford, is an early-stage venture capital firm investing in transformative healthcare and technology companies. The firm has a strong focus on medical technology, including medical devices and diagnostics, aiming to support innovations that improve patient outcomes. Canaan Partners is recognized for its collaborative approach, leveraging a team of experts to guide portfolio companies from inception through commercialization.
Location: Stamford CT
31. Lightstone Ventures
Lightstone Ventures, based in Portola Valley, California, is a venture capital firm specializing in early-stage investments in the biopharmaceutical and medical device sectors. The firm focuses on funding novel, disruptive technologies to transform patients' lives, with a portfolio that includes companies such as Willow, MicroVention, and Vigil Neuroscience. Lightstone Ventures partners with visionary founders to bring innovative therapeutics to patients in need, leveraging nearly 100 years of combined operational experience.
Location: Portola Valley CA
32. Catalyst Health Ventures (CHV)
Catalyst Health Ventures (CHV), based in Boston, Massachusetts, is a venture capital firm specializing in early-stage investments in transformative medical technologies. The firm focuses on therapeutic medical devices, diagnostics, and digital health solutions that address significant clinical needs and have the potential for meaningful market impact. CHV is recognized for its collaborative approach, working closely with entrepreneurs to provide strategic guidance and support throughout the development and commercialization process.
Location: Boston MA
33. Wavemaker 360
Wavemaker 360 Health, based in Pasadena, California, is a venture capital firm specializing in early-stage healthcare investments. The firm focuses on medical technology, including medical devices, diagnostics, and digital health solutions, aiming to improve patient outcomes and reduce healthcare costs. Wavemaker 360 is recognized for its extensive network of healthcare industry professionals, providing portfolio companies with strategic support and access to key industry connections.
Location: Pasadena CA
34. Mutual Capital Partners (MCP)
Mutual Capital Partners (MCP), based in Westlake, Ohio, is a venture capital firm specializing in early-stage investments in healthcare IT and medical device companies. The firm focuses on businesses with established customer bases, aiming to support innovations that address significant clinical needs. MCP is recognized for its active involvement in portfolio companies, providing strategic guidance and leveraging its extensive network to facilitate growth and commercialization.
Location: Westlake OH
35. Polaris Partners
Polaris Partners, based in Boston, Massachusetts, is a venture capital firm with over $5 billion in committed capital, specializing in early-stage investments in healthcare and technology sectors. The firm has a strong focus on medical technologies, including medical devices, diagnostics, and digital health solutions, aiming to support innovations that improve patient outcomes and address significant clinical needs. Polaris Partners is recognized for its collaborative approach, working closely with entrepreneurs and leveraging its extensive network to bring transformative healthcare solutions to market.
Location: Boston MA
36. Sanderling Ventures
Sanderling Ventures, based in San Mateo, California, is one of the oldest venture capital firms dedicated to building new biomedical companies. The firm specializes in early-stage investments in areas such as small molecule therapeutics, biologics and vaccines, drug delivery, platform technologies, medical devices, diagnostics, and digital health. Sanderling Ventures is recognized for its active management approach, working closely with entrepreneurs to develop and commercialize innovative biomedical technologies.
Location: San Mateo CA
37. Foothill Ventures
Foothill Ventures, based in Los Altos, California, is a seed-stage venture capital firm investing in companies across software, life sciences, and deep tech sectors. The firm focuses on startups demonstrating technical differentiation, particularly in areas like neuroscience, AI-enabled platforms, and digital healthcare. Foothill Ventures is recognized for its founder-friendly approach, providing rapid decision-making, transparent communication, and leveraging a strong network to support portfolio companies.
Location: Los Altos CA
38. HealthpointCapital
HealthpointCapital, based in San Diego, California, is a private equity firm exclusively focused on the musculoskeletal healthcare sector. With over $800 million in institutional capital, the firm specializes in investments across orthopedics, dental, maxillofacial, rehabilitation, and digital health industries. HealthpointCapital is recognized for its deep industry expertise, active mentorship, and strong relationships with strategic acquirers, enabling it to accelerate growth and create significant value for its portfolio companies.
Location: San Diego CA
39. Vensana Capital
Vensana Capital, based in Minneapolis, Minnesota, is a venture capital and growth equity firm dedicated to partnering with entrepreneurs aiming to transform healthcare through breakthrough innovations in medical technology. The firm invests in development and commercial-stage companies across the medtech sector, including medical devices, diagnostics, data science, drug delivery, digital health, life science tools, and tech-enabled services. With approximately $1 billion in capital under management, Vensana Capital focuses on supporting companies that have the potential to create new clinical standards of care while also making healthcare more efficient, accessible, and cost-effective.
Location: Minneapolis MN
40. Norwest Venture Partners (NVP)
Norwest Venture Partners (NVP), based in Menlo Park, California, is a diversified venture and growth equity firm managing $15.5 billion in capital. The firm focuses on early- to mid-stage investments across various healthcare sectors, including medical devices, diagnostics, and digital health solutions. NVP is recognized for its collaborative approach, working closely with entrepreneurs to build enduring companies that transform healthcare.
Location: Menlo Park CA
41. Fountain Healthcare Partners
Fountain Healthcare Partners, based in Dublin, Ireland, is a venture capital firm specializing in early-stage investments in life sciences companies across Europe and the United States. The firm focuses on sectors such as specialty pharmaceuticals, biotechnology, and medical devices, aiming to support entrepreneurs developing innovative technologies with clear clinical and commercial potential. Fountain Healthcare Partners is recognized for its active involvement in portfolio companies, providing strategic guidance and leveraging its extensive network to facilitate growth and commercialization.
Location: Dublin Ireland
42. Cultivation Capital
Cultivation Capital, based in St. Louis, Missouri, is a venture capital firm specializing in early-stage investments across various sectors, including life sciences and health technology. The firm focuses on startups in therapeutics, diagnostics, research tools, medical devices, and healthcare information technology. Cultivation Capital is recognized for its active involvement in portfolio companies, providing strategic guidance and leveraging its extensive network to facilitate growth and commercialization.
Location: St. Louis MO
43. Apple Tree Partners (ATP)
Apple Tree Partners, based in New York, is a venture capital firm investing in innovative life sciences and medical technology companies. The firm supports early- to growth-stage Medtech ventures, including medical devices and diagnostics. Apple Tree Partners is recognized for providing strategic guidance and operational resources to help Medtech innovations reach the market.
Location: New York NY
44. AlleyCorp
AlleyCorp, based in New York, is a venture capital firm and startup studio specializing in early-stage investments in healthcare and medical technology. The firm focuses on sectors such as digital health, value-based care, and life sciences, aiming to improve healthcare quality, cost, and access. AlleyCorp is recognized for its physician-led team and its commitment to building and investing in transformative healthcare companies.
Location: New York NY
45. Mighty Capital
Mighty Capital, based in San Francisco, is a venture capital firm specializing in early-growth investments across various sectors, including health AI and medical technology. The firm leverages its extensive network of over 500,000 product managers through its platform, Products That Count, to accelerate go-to-market strategies for its portfolio companies. Mighty Capital is recognized for its unique approach, combining capital investment with strategic access to a vast community of industry professionals.
Location: San Francisco CA
46. HealthCare Ventures
HealthCare Ventures, based in Cambridge, Massachusetts, is a venture capital firm specializing in early-stage investments in life sciences companies. The firm focuses on sectors such as therapeutics, diagnostics, medical devices, and healthcare technologies, aiming to support innovations that can transform patient care. HealthCare Ventures is recognized for its long-standing track record and commitment to advancing healthcare through strategic investments.
Location: Cambridge MA
47. Casdin Capital
Casdin Capital, based in New York, is a venture capital firm specializing in the life sciences sector, including medical technology. The firm focuses on investing in companies that leverage molecular information to drive innovation in healthcare, biotechnology, and synthetic biology. Casdin Capital is recognized for its disciplined approach, emphasizing patience, persistence, and strong relationships to create value and open new opportunities.
Location: New York NY
48. Pioneer Fund
Pioneer Fund, based in New York, is a venture capital firm specializing in early-stage investments in biotechnology, healthcare, and life sciences. The firm focuses on supporting founders innovating in these sectors, aiming to accelerate the development of transformative healthcare solutions. Pioneer Fund is recognized for its commitment to partnering with visionary teams to bring groundbreaking technologies to market.
Location: New York NY
49. Omega Funds
Omega Funds, based in Boston, is a venture capital firm investing in innovative life sciences and medical technology companies. The firm focuses on medical devices, diagnostics, and digital health solutions alongside therapeutics. Omega Funds is recognized for supporting companies that develop transformative Medtech innovations to improve patient care.
Location: Boston MA
50. Runway Growth Capital
Runway Growth Capital, based in Woodside, California, provides growth-stage and venture debt financing to companies in healthcare including MedTech. It offers senior secured term loans to medical device, diagnostics, and biotech firms as an alternative to raising equity capital. Runway Growth Capital is recognized for its flexibility and support to help MedTech companies extend runway, commercialize products, and scale without excessive dilution.
Location: Woodside CA
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