Top 100 Biotech Venture Capital (VC) Firms
Finding the right partner can make or break a biotech startup. This Biotech Venture Capital list presents the Top 100 Biotech Investors in the US, firms Actively investing in the United State updated for 2025. These VCs back companies across therapeutics (small molecules, oncology, immunology), Diagnostics, Med Tech and Digital Health, from early-stage seed to late-stage rounds. Use this list as a practical starting point for fundraising in 2025.
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The top 100 Biotech Venture Capital Firms
1. Flagship Pioneering
Flagship Pioneering is a venture creation firm that builds and funds breakthrough biotech and life sciences companies from the ground up. Known for founding Moderna, it focuses on pioneering disruptive platforms in human health and sustainability.
Location: Cambridge MA
2. ARCH Venture Partners
Arch Venture Partners is a venture capital firm that builds and invests in early-stage life sciences and biotechnology companies rooted in breakthrough scientific research. It specializes in turning lab innovations from universities and research institutions into transformative health technology ventures.
Location: Chicago IL
3. Third Rock Ventures
Third Rock Ventures is a venture capital firm that discovers, launches, and builds early-stage life sciences and biotechnology companies. It focuses on translating bold scientific ideas into innovative health ventures through close collaboration with founders and multi-disciplinary expertise.
Location: Boston MA
4. OrbiMed
OrbiMed is a global healthcare investment firm that supports companies across biopharmaceuticals, medical devices, diagnostics, digital health, and healthcare services. It uses a flexible investment approach, including equity, credit, and royalty financing to help life sciences ventures grow at various stages. The firm is known for providing tailored financing solutions combined with deep scientific and investment expertise.
Location: New York NY
5. New Enterprise Associates (NEA)
New Enterprise Associates (NEA) is a global venture capital firm investing in technology and healthcare companies at all stages of growth. The firm focuses on building enduring partnerships with ambitious founders to create transformational businesses. NEA's portfolio spans various sectors, including life sciences and digital health.
Location: Menlo Park CA
6. Atlas Venture
Atlas Venture is a venture capital firm focused on creating and investing in early-stage biotechnology companies. It specializes in building breakthrough biotech startups by partnering closely with scientists and entrepreneurs to translate innovative science into medicines. The firm operates from Cambridge, Massachusetts, and has been at the forefront of biotech innovation for over 30 years.
Location: Cambridge MA
7. 5AM Ventures
5AM Ventures is a venture capital firm focused on funding and building next-generation life sciences companies. It specializes in early-stage investments, often partnering with academic teams to establish proof-of-concept data that enables Series A financing. The firm emphasizes a hands-on approach, actively engaging in company building and strategic development.
Location: San Francisco CA
8. RA Capital Management
RA Capital Management is a multi-stage investment firm dedicated to evidence-based investing in healthcare and life sciences companies. It supports the development of drugs, medical devices, diagnostics, services, and research tools across various therapeutic areas. The firm combines scientific expertise with flexible financing strategies to advance innovations from discovery through commercialization.
Location: Boston MA
9. Versant Ventures
Versant Ventures is a healthcare venture capital firm focused on creating and investing in biotechnology companies. It operates through in-house Discovery Engines, collaborating with academic founders to translate scientific innovations into novel therapeutics. The firm has a global presence with offices in North America and Europe, emphasizing a hands-on approach to company building.
Location: San Francisco CA
10. Venrock
Venrock is a venture capital firm that invests in early-stage companies in healthcare and technology sectors. It partners with entrepreneurs to build transformative businesses, leveraging its deep expertise and long-standing history in the industry. The firm has a strong track record of supporting companies from inception through to successful exits.
Location: Palo Alto CA
11. SV Health Investors
SV Health Investors is a healthcare and life sciences venture capital and growth equity firm. It invests globally across therapeutics, medtech, and healthcare services, focusing on transformative innovations. With offices in Boston and London, the firm has a 30-year track record of supporting entrepreneurs in building breakthrough companies.
Location: Boston MA
12. Bain Capital Life Sciences
Bain Capital Life Sciences is a global investment firm focused on advancing medical innovation across the life sciences sector. It targets opportunities in pharmaceuticals, biotechnology, medical devices, diagnostics, and life science tools, aiming to improve patient outcomes through strategic investments. The firm leverages Bain Capital’s extensive healthcare expertise and resources to support companies addressing unmet medical needs.
Location: Boston MA
13. Deerfield
Deerfield is an investment firm dedicated to advancing healthcare through investment, intelligence, and philanthropy. It supports a diverse portfolio of private and public investments across therapeutics, medical devices, healthcare services, diagnostics, and digital health. The firm operates Deerfield Discovery and Development (3DC), an in-house R&D engine that collaborates with scientists and industry veterans to drive progress.
Location: New York NY
14. Foresite Capital
Foresite Capital is a multi-stage healthcare and life sciences investment firm focused on addressing significant unmet needs by funding promising businesses at all stages of their life cycles. The firm employs a data science-driven approach to invest in companies that leverage biology and big data to transform healthcare. Foresite Capital is headquartered in the San Francisco Bay Area with an office in New York City.
Location: Larkspur CA
15. Sofinnova
Sofinnova Ventures is a U.S.-based healthcare investment firm focused on early-stage biotechnology and life sciences companies. It partners with entrepreneurs to develop transformative therapeutics, leveraging deep scientific expertise and a collaborative approach. The firm has a track record of advancing drug development and navigating the regulatory process to potential FDA approval.
Location: Menlo Park CA
16. MPM Bio Impact
MPM BioImpact is a biotechnology investment firm with over 30 years of experience in creating and investing in innovative companies. It focuses on delivering transformative therapies to patients by investing in both private and public biotech companies. The firm is dedicated to impact investing, managing over $3 billion in assets across early-stage venture funds, private/public impact funds, and a public equities fund.
Location: Boston MA
17. Polaris Partners
Polaris Partners is a venture capital firm with over 25 years of experience investing in healthcare and technology companies. It partners with entrepreneurs to build transformational companies, leveraging its deep expertise and collaborative approach. The firm has a strong track record of supporting companies from inception through to successful exits.
Location: Boston MA
18. GV
GV is a venture capital firm investing in early-stage life sciences and healthcare companies. It focuses on transformative therapeutics, diagnostics, and health tech innovations. The firm collaborates with founders to accelerate breakthroughs aimed at improving patient outcomes.
Location: San Francisco CA
19. Abingworth
Abingworth is a transatlantic life sciences investment firm with over 50 years of experience. It focuses on developing innovative therapeutics by investing across all stages of a company's lifecycle, from seed to late-stage clinical development. The firm operates in key biotech hubs in London, Boston, and San Francisco, partnering closely with entrepreneurs to bring breakthrough science to patients.
Location: San Francisco CA
20. Canaan Partners
Canaan Partners is an early-stage venture capital firm investing in transformative ideas across healthcare and technology sectors. The firm focuses on seed and Series A investments, partnering with visionary entrepreneurs to build impactful companies. With over $6.8 billion in assets under management, Canaan has a track record of supporting companies from inception to successful exits.
Location: Stamford CT
21. Perceptive Advisors
Perceptive Advisors is a New York-based investment firm focused on the life sciences sector. It manages approximately $8 billion in assets, investing across the capital structure in both private and public companies. The firm employs a scientific approach to identify and support promising healthcare innovations, partnering with entrepreneurs to advance transformative therapies.
Location: New York NY
22. The Column Group (TCG)
The Column Group is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry. It employs an edge-to-edge investment model, supporting early technology platforms, single assets, and later-stage programs from inception through exit. Over its two-decade history, TCG has nurtured science into successful biotech ventures, having started and invested in 55 companies and generated $4.0 billion in returns for its partners and portfolio. The firm operates through a collaborative ecosystem of funds, each with a clear strategy and focus, maximizing success through joint action.
Location: San Francisco CA
23. VenBio Partners
VenBio Partners is a U.S.-based venture capital firm specializing in life sciences investments. Founded in 2011, the firm focuses on developing novel therapeutics to address unmet medical needs. VenBio actively partners with industry leaders to build impactful medicines and technologies. The firm has raised approximately $1.1 billion in committed capital across its funds.
Location: San Francisco CA
24. SR One
SR One is a transatlantic biotechnology venture capital firm dedicated to translating innovative science into medicines. It employs a "back-and-build" approach, focusing on companies with strong fundamentals and novel therapeutic strategies. With offices in Redwood City, California, and London, UK, SR One partners with entrepreneurs to advance transformative therapies across various disease areas.
Location: Redwood City CA
25. Longitude Capital
Longitude Capital is a U.S.-based venture capital firm specializing in growth-stage investments within the life sciences sector. Founded in 2006, the firm focuses on biotechnology, medical technology, and health solutions companies aiming to improve clinical outcomes, enhance patient quality of life, and reduce the cost of care. With over $2 billion raised across six funds, Longitude Capital employs a balanced portfolio strategy, investing in both clinical-stage and commercial-stage companies.
Location: Menlo Park CA
26. Novo Holdings
Novo Holdings is a global life sciences investor managing over €142 billion in assets. It invests across the entire life sciences spectrum, from early-stage startups to mature companies, focusing on pharmaceuticals, biotechnology, medical technology, healthcare services, and industrial biosolutions. The firm operates with a long-term investment horizon, leveraging its extensive healthcare expertise to support companies in addressing human health challenges and promoting sustainability.
Location: Boston MA
27. Longwood Fund
Longwood Fund is a Boston-based venture capital firm specializing in the creation and investment of early-stage life sciences companies. The firm collaborates closely with leading scientists and entrepreneurs to develop novel therapies addressing significant unmet medical needs. With over $650 million in assets under management, Longwood has co-founded 24 companies, resulting in more than 20 launched or marketed products and over two dozen clinical-stage assets .
Location: Boston MA
28. Northpond Ventures
Northpond Ventures is a science-driven venture capital firm based in Cambridge, MA; San Francisco, CA; and Bethesda, MD. It invests in biotechnology, digital health, and life sciences businesses. The firm focuses on building and supporting breakthrough science and technology-driven businesses to create a marked impact on humanity. Northpond Ventures has been named one of the most active lead biotech investors in 2021 by Crunchbase and the most active lead investor in life science solutions and molecular diagnostics by Silicon Valley Bank.
Location: Cambridge MA
29. IQT
In-Q-Tel is a U.S.-based strategic investor that supports emerging life sciences and biotechnology innovations. It collaborates with startups to advance scientific technologies that can be applied to healthcare and national security challenges.
Location: Arlington VA
30. Pillar VC
Pillar VC is a Boston-based venture capital firm that invests in early-stage life sciences and biotechnology startups. It partners with scientists and founders to translate academic research into transformative companies in healthcare and other sectors.
Location: Boston MA
31. Curie.Bio
Curie.Bio is a Boston-based biotech accelerator and venture capital firm focused on supporting early-stage therapeutics companies. It offers seed funding and hands-on drug discovery expertise to founders, aiming to advance promising therapeutic ideas into clinical-stage companies. The firm has raised over $1.2 billion and invested in 26 startups since its inception.
Location: Boston MA
32. Illumina Ventures
Illumina Ventures is an independent venture capital firm based in California, specializing in early-stage investments in genomics and precision health. Leveraging a strategic partnership with Illumina Inc., the firm focuses on areas such as life sciences tools, diagnostics, therapeutics, and sustainability. Through Illumina Ventures Labs, it provides startups with capital, sequencing capabilities, mentorship, and fully equipped genomics labs to accelerate value creation from company formation to Series A startups.
Location: Foster City CA
33. M Ventures
M Ventures is the strategic corporate venture capital arm of Merck KGaA, Darmstadt, Germany, investing in biotechnology and technology sectors. The firm focuses on areas such as healthcare drug development, life science tools, electronics, and frontier technology & sustainability. M Ventures aims to invest in visionary companies that address challenging diseases, empower scientists with cutting-edge research and development tools, and develop innovative solutions for sustainability and technology convergence.
Location: Los Angeles CA
34. Pfizer Venture Investments
Pfizer Ventures is the corporate venture capital arm of Pfizer Inc., focusing on early-stage investments in transformative therapeutics. The firm targets areas aligned with Pfizer's core therapeutic interests, including oncology, inflammation and immunology, internal medicine, vaccines, and neuroscience. With a capital commitment of $600 million, Pfizer Ventures seeks to enhance Pfizer's pipeline by supporting emerging companies developing innovative medicines and technologies .
Location: New York NY
35. F-Prime Capital Partners
F-Prime Capital is a global venture capital firm investing in life sciences, therapeutics, and medtech. It partners with entrepreneurs to advance innovative healthcare solutions from early-stage to growth companies.
Location: Cambridge MA
36. Boxer Capital
Boxer Capital is a San Diego-based biotechnology investment firm specializing in specialized and precision medicine. The firm invests across the entire drug development lifecycle, from early-stage preclinical discovery to late-stage clinical and commercial-stage companies. Boxer Capital focuses on identifying transformative medical advancements through fundamental, research-based investing in private and public markets.
Location: San Diego, CA
37. KdT Ventures
KdT Ventures is an early-stage venture capital firm based in Austin, Texas, focusing on science-driven companies at the intersection of technology and the physical world. The firm invests in areas such as biotechnology, healthcare, sustainability, and engineering, partnering with founders to re-architect the world at a molecular level. KdT Ventures provides deep technical and strategic support to build transformative companies from inception through various stages of growth.
Location: Austin TX
38. Vivo Capital
Vivo Capital is a global healthcare investment firm based in Palo Alto, California, focusing exclusively on life sciences. Founded in 1996, the firm employs a multi-strategy investment approach encompassing venture capital, growth equity, buyouts, and public equity. With approximately $5.3 billion in assets under management, Vivo has invested in over 430 companies worldwide, spanning biotechnology, pharmaceuticals, medical devices, and healthcare services. The firm maintains a global presence with offices in Asia and a team of over 75 professionals.
Location: Palo Alto CA
39. Apple Tree Partners (ATP)
Apple Tree Partners is a life sciences venture capital firm specializing in the creation and development of biotechnology companies. The firm provides flexible capital and strategic support, partnering with scientists to advance innovative therapeutics from early-stage concepts to clinical trials.
Location: New York NY
40. Breakout Ventures
Breakout Ventures is a San Francisco-based venture capital firm investing in early-stage companies developing research-based solutions to improve human health and sustainability. The firm focuses on the convergence of biology, chemistry, and technology, supporting science-driven companies from seed to scale. Breakout Ventures is committed to helping entrepreneurs reach critical milestones and build value, leveraging a network of experts to advance innovative ideas and forge lifelong connections.
Location: San Francisco CA
41. Elevate Ventures
Elevate Ventures is a venture capital firm based in Indiana, focusing on early-stage investments in innovation-driven companies across various sectors, including life sciences. The firm provides funding and strategic guidance to entrepreneurs at pre-seed, seed, and Series A stages, aiming to accelerate the growth of startups and foster economic development in the region.
Location: Indianapolis IN
42. Biomark Capital
BioMark Capital is a venture capital firm based in Greenwich, Connecticut, specializing in early to late-stage investments in life sciences companies. The firm focuses on sectors such as diagnostics, therapeutics, medical devices, and digital health, aiming to support innovative approaches that can transform healthcare. BioMark Capital partners with entrepreneurs to accelerate growth and build successful business ventures, sharing the drive and vision of its portfolio companies.
Location: Greenwich CT
43. Global BioAccess Fund
Global BioAccess Fund is a New York-based venture capital firm investing in early-stage companies developing novel therapeutics and medical devices. The firm focuses on addressing unmet medical needs in oncology, cardiovascular, central nervous system disorders, and rare diseases. Global BioAccess Fund provides capital to support Investigational New Drug (IND) submissions and clinical trials, partnering with forward-thinking companies to accelerate the development of transformative healthcare solutions.
Location: New York NY
44. BioGenerator
BioGenerator Ventures is an early-stage venture capital firm based in St. Louis, Missouri, focusing on life sciences investments. The firm creates, builds, and invests in companies addressing significant challenges in human health and agriculture. BioGenerator Ventures has invested in over 130 companies, leveraging its extensive network and resources to support the growth of innovative startups.
Location: St. Louis MO
45. Fifty Years
Fifty Years is a San Francisco-based venture capital firm focused on pre-seed and seed-stage investments in life sciences and technology. The firm partners with scientists and engineers to translate breakthrough research into companies addressing global challenges such as disease, climate change, and malnutrition. Through initiatives like 5050 and the Spinout Playbook, Fifty Years actively supports the commercialization of academic innovations.
Location: San Francisco CA
46. Hatteras Venture Partners
Hatteras Venture Partners is a venture capital firm based in Durham, North Carolina, specializing in seed- and early-stage investments in life sciences. The firm focuses on biotechnology, medtech, and healthtech sectors, aiming to build transformational companies that improve human health. With over $900 million in capital across seven funds, Hatteras partners with entrepreneurs to advance innovative therapies and technologies.
Location: Durham NC
47. Civilization Ventures
Civilization Ventures is a San Francisco-based venture capital firm investing in early-stage life sciences and digital health companies. It focuses on genomics, diagnostics, and synthetic biology, supporting founders to develop transformative healthcare innovations.
Location: San Francisco CA
48. New Science Ventures (NSV)
New Science Ventures (NSV) is a venture capital firm based in Connecticut and London, investing in early- and late-stage companies leveraging novel scientific approaches in life sciences and information technology. The firm focuses on therapeutics, medical devices, and diagnostics, supporting innovations addressing significant unmet needs. NSV's portfolio includes companies like Ventyx Biosciences and NorthSea Therapeutics, reflecting its commitment to advancing breakthrough science.
Location: Greenwich CT
49. Vida Ventures
Vida Ventures is a life sciences venture capital firm investing in early- and late-stage companies developing transformative biomedical therapies. Founded in 2017 by scientists, physicians, and entrepreneurs, the firm focuses on areas such as oncology, immunology, and genetic diseases. Vida Ventures has a portfolio that includes companies like A2 Biotherapeutics, Aktis Oncology, and Affini-T Therapeutics.
Location: Los Angeles CA
50. Lightstone Ventures
Lightstone Ventures is a venture capital firm based in Portola Valley, California, founded in 2012. The firm specializes in early-stage investments in life sciences, focusing on both biopharmaceuticals and medical technologies. Lightstone Ventures partners with visionary founders to translate novel scientific breakthroughs into clinically and commercially meaningful therapies. With nearly 100 years of combined operational experience, the team has been involved in over 20 IPOs and 19 acquisitions, demonstrating a strong track record in building successful healthcare companies.
Location: Portola Valley CA
51. RiverVest Venture Partners
RiverVest Venture Partners is a venture capital firm based in St. Louis, Missouri, specializing in early-stage investments in life sciences companies. The firm focuses on biopharmaceuticals and medical devices, aiming to address significant unmet medical needs. With over $1.6 billion in assets under management, RiverVest has a track record of founding and funding companies that have developed commercial products treating patients.
Location: St. Louis MO
52. Harmonix
Harmonix Fund is an early-stage venture capital firm based in La Quinta, California, specializing in investments at the intersection of healthcare, life sciences, and deep tech. The firm partners with exceptional entrepreneurs to advance human health and improve quality of life through meaningful innovations. Harmonix Fund's multidisciplinary team brings decades of experience and a shared commitment to driving transformative change in these sectors.
Location: La Quinta CA
53. Life Extension Ventures
LifeX Ventures is a New York-based venture capital firm investing in early-stage life sciences companies. The firm focuses on areas such as biotechnology, pharmaceuticals, medical devices, diagnostics, and digital health solutions. LifeX Ventures aims to accelerate scientific innovation and commercialization by leveraging AI and software technologies.
Location: New York NY
54. BioAdvance
BioAdvance Capital is an evergreen venture fund based in Conshohocken, Pennsylvania, focusing on early-stage life sciences investments. The firm targets companies developing therapeutics, medical devices, diagnostics, digital health solutions, and research tools. BioAdvance primarily invests in the Mid-Atlantic region, aiming to enhance human health and quality of life. Since 2003, it has committed over $55 million to approximately 100 organizations, with its portfolio companies attracting more than $4.2 billion in follow-on funding. Notable investments include ImmunoGenesis, Spirovant, and Tolerance Bio.
Location: Conshohocken PA
55. Alix Ventures
Alix Ventures is a San Francisco-based venture capital firm investing in early-stage life sciences companies. The firm focuses on "TechBio" startups that engineer biology using computational and automation tools to accelerate therapeutics, diagnostics, and biomanufacturing. Alix Ventures supports founders with technical rigor, industry insights, and a community of experts to drive patient impact.
Location: San Francisco CA
56. Casdin Capital
Casdin Capital is a New York-based venture capital firm investing in the life sciences revolution. The firm focuses on healthcare, biotechnology, synthetic biology, and technology sectors, partnering with companies to create value and open new opportunities. Casdin Capital emphasizes patience, persistence, and strong relationships, aiming for big markets and investing in great ideas and teams while maintaining a disciplined and principled approach.
Location: New York NY
57. Alta Partners
Alta Partners is a venture capital firm specializing in early-stage investments in life sciences and healthcare companies. Since its founding in 1996, the firm has raised over $2.8 billion across 12 funds and has been instrumental in the development of more than 75 FDA-approved products. Alta Partners focuses on areas such as biotechnology, medical devices, diagnostics, and healthcare services, aiming to support entrepreneurs in building high-impact companies that improve patient outcomes.
Location: Jackson WY
58. Adjuvant Capital
Adjuvant Capital is a New York-based venture capital firm investing in life sciences technologies addressing high-burden public health challenges. The firm focuses on diseases such as malaria, tuberculosis, and antimicrobial resistance, aiming to accelerate the development of medical innovations for underserved populations. Adjuvant Capital's debut fund, launched in 2019, raised $300 million from investors including the Bill & Melinda Gates Foundation, Merck, and Novartis.
Location: New York NY
59. Novartis Venture Fund
Novartis Venture Fund is a corporate venture capital firm investing in early- and late-stage life sciences companies. With over USD 750 million in committed capital, NVF focuses on biotechnology and biopharmaceuticals, aiming to address unmet patient needs. The fund has supported more than 40 portfolio companies across North America and Europe, with a track record of successful exits through IPOs and mergers and acquisitions.
Location: Cambridge MA
60. Questa Capital
Questa Capital is a U.S.-based venture capital firm investing in early- and growth-stage healthcare companies. The firm partners with exceptional teams building the next generation of breakout healthcare companies, focusing on innovations that elevate patient experiences, reduce costs, and improve health outcomes. Questa Capital's portfolio includes companies like Avive, Bicycle Health, Calyxo, ClaritasRx, Cortica, and DispatchHealth, which are transforming various aspects of healthcare delivery and patient care.
Location: Washington DC
61. Vensana Capital
Vensana Capital is a Minneapolis-based venture capital and growth equity firm focused on partnering with entrepreneurs to transform healthcare through breakthrough innovations in medical technology. The firm actively invests in development and commercial stage companies across the medtech sector, including medical devices, diagnostics, data science, drug delivery, digital health, life science tools, and tech-enabled services. Since its inception in 2019, Vensana has raised approximately $1 billion in capital and has partnered with over 20 companies, achieving six exits totaling nearly $3 billion in value.
Location: Minneapolis MN
62. Westlake Village BioPartners
Westlake BioPartners is a venture capital firm specializing in early-stage life sciences investments. The firm focuses on incubating next-generation biotech companies, providing hands-on support from ideation through clinical and commercial stages. Since its inception in 2018, Westlake has raised $1.3 billion across three funds and has launched over 20 companies, including Capsida Biotherapeutics and Acelyrin.
Location: Westlake Village CA
63. Artiman
Artiman Ventures is a Palo Alto-based venture capital firm investing in early-stage companies across healthcare, information technology, and manufacturing. The firm focuses on innovative opportunities that create or disrupt large markets, supporting founders with strategic guidance and growth capital.
Location: Palo Alto CA
64. Healthspan Capital
Healthspan Capital is a venture capital firm based in El Cerrito, California, specializing in early-stage investments in longevity biotechnology ("LongBio") and regenerative medicine. The firm focuses on therapeutics aimed at extending healthy human lifespan, investing in pre-seed to Series A companies. Founded in 2021 by Sebastian Brunemeier, Nathan Cheng, and Michael Chinen, Healthspan Capital was the first publicly accessible longevity venture fund listed on AngelList. The firm has completed approximately 30 deals in the last two years, making it one of the most active investors in the longevity biotech space.
Location: El Cerrito CA
65. Dolby Family Ventures
Dolby Family Ventures is a San Francisco-based venture capital firm investing in early-stage companies addressing complex science and engineering challenges. The firm focuses on precision neuroscience, life sciences platforms, aerospace, climate tech, and digital deep tech, supporting visionary entrepreneurs with a long-term, collaborative approach. Since its inception in 2014, Dolby Family Ventures has invested in approximately 100 companies across these sectors.
Location: San Francisco CA
66. Fountain Healthcare Partners
Fountain Healthcare Partners is a venture capital firm, specializing in early-stage investments in life sciences companies. The firm focuses on sectors such as specialty pharmaceuticals, biopharmaceuticals, medical devices, and diagnostics, investing primarily in Europe and the United States. Fountain Healthcare Partners manages three funds totaling €301 million and typically invests between €10 million and €15 million per company. The firm aims for strong exits within 4 to 6 years and is committed to responsible investing.
Location: New York NY
67. Catalyst Health Ventures (CHV)
Catalyst Health Ventures (CHV) is a Boston-based venture capital firm that invests in transformative medical technologies addressing global unmet healthcare needs. The firm focuses on therapeutic medical devices, diagnostics, and digital health, supporting companies from early product development through to exit. CHV collaborates closely with management teams and syndicate partners to build successful companies, aiming to significantly improve patient outcomes and establish new standards of care.
Location: Boston MA
68. Borealis Ventures
Borealis Ventures is a Hanover-based venture capital firm investing in early-stage life sciences, digital health, and animal health companies. The firm partners with entrepreneurs to build transformative healthcare and technology companies, leveraging its strong local network and expertise.
Location: Hanover NH
69. Medical Excellence Capital (MEC)
Medical Excellence Capital (MEC) is a New York-based early-stage venture firm specializing in precision health innovations. The firm invests in transformative life sciences technologies, including gene and cell therapies, synthetic biology, and AI-driven drug discovery, leveraging a proprietary network of leading physician-scientists. Founded in 2020 by John Prufeta, MEC combines seasoned investors and operators with a national medical network to accelerate the development of novel therapeutics and address significant unmet medical needs.
Location: New York NY
70. AlleyCorp
AlleyCorp is a New York-based venture firm founded by Kevin Ryan, specializing in early-stage investments and company creation. The firm focuses on sectors including healthcare, economic infrastructure, and deep tech, with a portfolio that includes companies like MongoDB, Zola, and Nomad Health. AlleyCorp's team combines entrepreneurial expertise with operational experience to support the growth of transformative companies.
Location: New York NY
71. Wireframe Ventures
Wireframe Ventures is a California-based venture capital firm founded in 2016, specializing in early-stage investments in technology-driven startups across the United States. The firm focuses on sectors including artificial intelligence, fintech, and health tech, aligning well with their goal of backing groundbreaking tech companies. Wireframe Ventures typically invests in early-stage startups with ticket sizes ranging from $500,000 to $2 million, providing the necessary capital and guidance to fuel their growth and success in today's competitive tech landscape.
Location: San Francisco CA
72. JAZZ Venture Partners
Jazz Venture Partners is a San Francisco–based venture capital firm founded in 2015 that invests in early-stage companies focused on enhancing human performance through science, wellness, healthcare, enterprise and consumer technology. It shows some relevance to life sciences and biotech by backing startups in neurological health, digital therapeutics, and biotech-infused platforms.
Location: San Francisco CA
73. Horizons Ventures
Horizons Ventures is a Hong Kong-based venture capital firm founded in 2002 that invests across early-stage to late-stage companies in sectors such as artificial intelligence, fintech, healthcare technology, and SaaS. While not exclusively a biotech life sciences investor, its healthcare technology investments occasionally intersect with life sciences innovation through health-focused technology startups.
Location: Hong Kong
74. MedMountain Ventures
MedMountain Ventures is a Utah-based physician-founded venture capital firm that invests early in healthcare innovators by offering far more than capital through hands-on support and deep operational and clinical expertise. The firm focuses on life sciences and healthcare tech startups, identifying promising technologies early in their development cycle to help them become world-class enterprises.
Location: Salt Lake City UT
75. Sanderling Ventures
Sanderling Ventures is a San Mateo-based venture capital firm founded in 1979 that is among the longest-standing investors exclusively dedicated to building biomedical companies. It focuses on early-stage opportunities in small molecule therapeutics, biologics and vaccines, drug delivery, platform technologies, medical devices, diagnostics, and digital/eHealth, offering both capital and hands-on management support.
Location: San Mateo CA
76. S32
S32 is a California-based venture capital firm founded by Bill Maris that invests broadly across frontier technologies including AI, computational biology, precision medicine, and biotech. It occasionally crosses into life sciences via investments in computational biology and healthcare-focused AI ventures.
Location: Los Altos CA
77. Sila B
Sila B Health Ventures is a Silicon Valley–based boutique venture capital firm that invests in early-stage biopharma startups addressing chronic diseases linked to aging. The firm operates micro-funds and provides founders with small equity checks alongside strategic advisory, execution support, and access to expert networks.
Location: San Francisco CA
78. Foothill Ventures
Foothill Ventures is a Los Altos, California–based technology-focused venture fund that invests in pre-seed through Series A startups across software, life sciences, and deep tech. While not exclusively biotech, its portfolio includes ventures in synthetic biology and therapeutics development, showing a willingness to support life sciences innovation.
Location: Los Altos CA
79. Harpoon Ventures
Harpoon Ventures is a San Diego-based venture capital firm founded in 2018 that invests in deep tech, AI, cybersecurity, aerospace, and biotech and biosecurity, with a particular focus on dual-use technologies serving both commercial and national security needs. The firm actively supports its portfolio by helping startups secure U.S. government contracts and strategic partnerships for accelerated growth.
Location: San Diego CA
80. Pappas Capital
Pappas Ventures is a life-science-focused venture capital firm based in Durham, North Carolina, founded in 1994 that invests in early- to mid-stage therapeutics, devices, and diagnostics across the U.S. and Canada. The firm offers hands-on operational support and has a history of notable exits including acquisitions and IPOs among its portfolio companies.
Location: Durham NC
81. Artis Ventures
Artis Ventures is a San Francisco–based venture capital firm founded in 2018 that invests in data-driven life sciences companies leveraging engineering, AI, and strong datasets to solve global health challenges. The firm focuses on scalable medical technologies with broad indications for healthcare and life sciences, aiming to improve health outcomes or cure diseases.
Location: San Francisco CA
82. Arboretum Ventures
Arboretum Ventures is a healthcare-focused venture capital firm based in Ann Arbor, Michigan, founded in 2002. The firm invests in early-stage companies across medical devices, life science tools, diagnostics, and tech-enabled care delivery, with a strong presence in under-ventured markets.
Location: Ann Arbor MI
83. DeepWork Capital
DeepWork Capital is an early-stage venture capital firm based in Orlando, Florida, founded in 2015, that invests in technology and life sciences startups, primarily in underserved U.S. regions like Florida. The firm targets Seed and Series A companies, often being the first institutional capital after angel investors, and focuses on sectors such as med-tech, therapeutics, diagnostics, and digital health.
Location: Orlando FL
84. Plum Alley Investments
Plum Alley is a New York–based venture capital firm founded in 2011 that invests in frontier technologies and medical breakthroughs led by women and gender-diverse founding teams. The firm supports its portfolio through a unique ecosystem providing infrastructure, technology, and support services to female domain expert general partners, aiming to drive innovation and impact across various sectors.
Location: New York NY
85. GreatPoint Ventures
GreatPoint Ventures is a San Francisco–based early-stage venture capital firm founded in 2015 by entrepreneurs with over 100 years of combined experience. The firm invests in transformative companies across sectors like biotech, healthtech, AI, and foodtech, emphasizing deep operational involvement and long-term partnerships.
Location: San Francisco CA
86. Pangaea Ventures
Pangaea Ventures is a Vancouver-based venture capital firm founded in 2000 that invests in early- to growth-stage companies leveraging advancements in materials science, chemistry, and biology to address global challenges. The firm focuses on hard tech innovations with applications in sectors such as clean energy, industrial manufacturing, and life sciences, aiming to drive sustainable impact through its investments.
Location: Vancouver
87. Kleiner Perkins
Kleiner Perkins is a Menlo Park–based venture capital firm founded in 1972 that invests in early-stage companies across sectors including technology, life sciences, and healthcare. The firm has a history of backing transformative companies such as Genentech and continues to focus on innovations that address global challenges.
Location: Menlo Park CA
88. 8VC
8VC is a venture capital firm founded in 2015 that invests in transformative companies across sectors including life sciences, technology, and defense. The firm focuses on building and supporting companies that leverage data-driven biology and advanced technologies to address complex global challenges.
Location: Austin TX
89. Lux Capital
Lux Capital is a New York–based venture capital firm founded in 2000 that invests in emerging technologies across sectors including life sciences, AI, and aerospace. The firm focuses on companies at the intersection of science and technology, aiming to turn science fiction into science fact.
Location: New York NY
90. Cottonwood Technology
Cottonwood Technology Fund is an early-stage venture capital firm based in Santa Fe, New Mexico, with additional offices in Denver, Colorado, and Enschede, the Netherlands. The firm specializes in investing in patent-based deep tech startups across sectors such as photonics, nanotechnology, health sciences, and advanced manufacturing, with a geographical focus on the Southwest United States and Northwest Europe.
Location: Santa Fe NM
91. DCVC Bio
DCVC Bio is a Silicon Valley–based venture capital firm founded in 2018 that invests in early-stage deep tech startups at the intersection of life sciences and artificial intelligence. The firm focuses on computational biology, synthetic biology, and sustainable agriculture, aiming to address global health and environmental challenges.
Location: Palo Alto CA
92. B Capital
B Capital Group is a global venture capital firm founded in 2015 by Facebook co-founder Eduardo Saverin and Raj Ganguly, with over $8 billion in assets under management. The firm invests across technology, healthcare, and climate sectors, supporting companies from early to late stages through its strategic partnership with the Boston Consulting Group (BCG).
Location: Los Angeles CA
93. Venture Science
Venture Science is a San Francisco–based growth-stage investment firm founded in 2012 that utilizes advanced analytical frameworks, including decision theory and artificial intelligence, to evaluate investment opportunities in both venture and public markets. The firm focuses on technology-driven companies across sectors such as AI, space technology, and life sciences, aiming to identify high-growth opportunities through rigorous probabilistic modeling and computational approaches.
Location: San Francisco CA
94. Elm Street Ventures
Elm Street Ventures is a New Haven–based seed and early-stage venture fund founded in 2006, with Yale University as its largest investor. The firm focuses on companies with a Yale connection, typically technology developed at and licensed from Yale, and invests in sectors such as therapeutics, advanced tools and materials for industry, and critical interventions for a warming planet.
Location: New Haven CT
95. Mission Biocapital
Mission BioCapital is a venture capital firm founded in 2009 that provides early-stage capital to life sciences startups, focusing on therapeutics, diagnostics, medical devices, and drug delivery. The firm partners with life sciences incubators to offer shared lab spaces and strategic guidance, helping startups progress from idea to exit.
Location: San Francisco CA
96. OCA Ventures
OCA Ventures is a Chicago-based venture capital firm founded in 2007 that invests in early-stage companies across sectors including healthcare, fintech, and enterprise software. The firm focuses on identifying and supporting high-growth companies with strong management teams and innovative solutions.
Location: Chicago IL
97. Global Health Investment Corporation
Global Health Investment Corporation is a nonprofit venture capital firm founded in 2012 that invests in life-saving health technologies for low- and middle-income countries. The firm supports companies developing vaccines, therapeutics, diagnostics, and medical devices to improve global health outcomes.
Location: New York NY
98. CincyTech
CincyTech is a Cincinnati-based venture capital firm founded in 2007 that invests in early-stage life sciences and digital technology companies in Southwest Ohio and the Midwest. The firm partners with innovative founders to transform ideas into high-potential companies, focusing on sectors such as healthcare, AI, and enterprise software.
Location: Cincinnati OH
99. eLab Ventures
eLab Ventures is an early-stage venture capital firm based in Ann Arbor, Michigan, founded in 2012, that invests in AI-driven technology startups across various sectors. The firm focuses on companies at the pre-seed, seed, and Series A stages, aiming to support disruptive innovations with capital-efficient business models.
Location: Ann Arbor MI
100. GoAhead Ventures
GoAhead Ventures is a Silicon Valley–based early-stage venture capital firm founded in 2015 that invests in pre-seed and seed stage companies across all technology sectors and geographies. The firm leads early stage deals with checks from $200K to $1M, aiming to innovate and break the venture capital mold.
Location: Menlo Park CA
For a more detailed version including investment stages, focus areas, and direct partner emails check out our full Biotech VC dataset :
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